SHELLEY; ROBERT D (Total 51 Patents Found)

Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases....
The present invention has many inherent advantages, such as we provide "A VERTICAL LIFT TOWING DOLLY INCLUDING VARIABLE, ATTACHABLE PLATFORMS" with each platform being individually designed for a specific purpose, such as hauling a boat, car, motorcycle, etc. Also, a unique hydraulic one-man operated cable syst...
Compounds of Formula (I), in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases....
本发明披露式I化合物,其中A,B,R1,R1a,R2,R3,R4,R5,R6及R7均具有本申请说明书中所限定的含义,所述化合物为受体酪胺酸抑制剂,可用于治疗免疫细胞有关的疾病与病症,诸如炎症与自身免疫疾病。...
Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R ...
A composite fused quartz material is disclosed for processing semiconductor grade silicon material in an improved manner. The modified vitreous material includes a disperse phase of fine size silicon metal particles which are distributed in preselected regions of the fused quartz matrix as a means of exercising tempera...
A crucible in which a semiconductor material is melted and held during a crystal growing process. The crucible includes a body of vitreous silica having a bottom wall and a sidewall formation extending up from the bottom wall and defining a cavity for holding the molten semiconductor material. The sidewall formation ha...
A server fulfills region and time of interest (RTI) requests for images from multiple users. The server includes a receiver for receiving a RTI request from a user, a processor for assembling a compressed image based on the RTI request, and a transmitter for transmitting the compressed image to the user. The processor ...
A method of designing the appearance of an article having steps of creating a digital file of a design configuration for an article, representing the design configuration on a computer screen, selecting or creating a color for a coating composition to be applied to the article, generating color data for the created col...
L'invention porte sur des bioanodes, des biocathodes et des cellules à biocarburant comprenant: un conducteur d'électrons, au moins une organelle anode ou une organelle cathode et un matériau d'immobilisation des organelles. L'organelle anode est capable de réagir avec un carburant liquide pour prod...
A crucible in which a semiconductor material is melted and held during a crystal growing process. The crucible includes a body of vitreous silica having a bottom wall and a sidewall formation extending up from the bottom wall and defining a cavity for holding the molten semiconductor material. The sidewall formation ha...
Compounds of Formula (I), in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases....
一种加固直拉工艺中容纳熔融半导体材料的坩埚和阻止此工艺中位错形成的方法,所说坩埚包括有内外表面的底壁和侧壁及其构成的腔的石英本体,在低于约600℃温度下,在侧壁内表面上淀积第一反玻璃化促进剂,淀积是这样的:将坩埚加热...
A method of designing the appearance of an article having steps of creating a digital file of a design configuration for an article, representing the design configuration on a computer screen, selecting or creating a color for a coating composition to be applied to the article, generating color data for the created col...
Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: ...
Bioanodes, biocathodes, and biofuel cells comprising an electron conductor, at least one anode organelle or cathode organelle, and an organelle immobilization material. The anode organelle is capable of reacting with a fuel fluid to produce an oxidized form of the fuel fluid, and capable of releasing electrons to the e...
The gusseted pillow includes a top fabric section, a bottom fabric section and an intermediate gusset portion, wherein the peripheries of the top and bottom fabric sections are each longer than a total length of the gusset portion. The peripheral edges of the top and bottom fabric sections are attached, respectively, t...
A method of reinforcing a crucible for the containment of molten semiconductor material in a Czochralski process, and of inhibiting formation of dislocations within a single crystal grown by the process. The crucible includes a body of vitreous silica having a bottom wall and a sidewall formation extending up from the ...
Individual pairs of shoes are packaged in bags instead of individual shoe boxes. Each shoe bag can be decoratively printed with, e.g., product logos or other information identifying the manufacturer of the shoes contained in the bag. The bags are made from paper and/or other types of materials. One or more display subu...
【課題】PIMキナーゼ阻害作用を有し、癌、自己免疫疾患、炎症性疾患等の治療に有用な新規トリアゾロピリジン化合物の提供。 【解決手段】下記式Iで表される化合物またはその医薬的に許容される塩。 (Aは、4〜7員の...
Compounds of Formula (I), in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases....
Microfluidic biofuel cells comprising a bioanode and/or a biocathode are formed using microfluidic principles and soft lithography. The enzymes utilized in the redox reactions at the bioanode and/or the biocathode are stabilized in a micellar or inverted micellar structure. The biofuel cell is used to produce high powe...
A composite fused quartz material is disclosed for processing semiconductor grade silicon material in an improved manner. The modified vitreous material includes a disperse phase of fine size silicon metal particles which are distributed in preselected regions of the fused quartz matrix as a means of exercising tempera...
本发明披露式I化合物,其中A,B,R1,R1a,R2,R3,R4,R5,R6及R7均具有本发明说明书中所限定的含义,所述化合物为受体酪胺酸抑制剂,可用于治疗免疫细胞有关的疾病与病症,诸如炎症与自身免疫疾病。...
미세유체 원리 및 소프트 리소그래피를 사용하여 바이오애노드 및/또는 바이오캐소드를 포함하는 미세유체 바이오연료 전지가 형성된다. 바이오애노드 및/또는 바이오캐소드에서의 산화환원 반응에서 사용된 효소는 마이셀 또는 역 마이셀 ...
Compounds of Formula (I), in which A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases....
Selon l'invention, des paires de chaussures individuelles sont emballées dans des sacs au lieu d'être emballées dans des boîtes de chaussures individuelles. Chaque sac peut être imprimé à des fins de décoration avec, par exemple, des logos de produits ou d'autres informations permettant d'identi...
一种加固直拉工艺中容纳熔融半导体材料的坩埚和阻止此工艺中位错形成的方法,所说坩埚包括有内外表面的底壁和侧壁及其构成的腔的石英本体,在低于约600℃温度下,在侧壁内表面上淀积第一反玻璃化促进剂,淀积是这样的:将坩埚加热...
Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases....
Compuesto de fórmula general I: o una sal farmacéuticamente aceptable del mismo, en el que: A es OR10 o NR11R12; B es H, F, Cl, ORa, (alquilo de 1-6C)NRbRC, (alquilo de 1-6C)OH, CH(OH)CH2OH, o (alquilo de 1-4C); R1 es H, F, Cl, Br, Me, ciclopropilo o CN; R1a, R2, R3 y R4 son independientemente H, F, Cl, Br, Me o CN; ...
A method for fabricating fused quartz crucibles is disclosed. Quartz sand is placed in a rotating fusion pot and takes on the shape of a bowl as a result of centrifugal forces. The quartz sand is heated to a temperature sufficient to melt and fuse the quartz sand together. A fast diffusing gas such as helium or hydroge...
A method of reinforcing a crucible for the containment of molten semiconductor material in a Czochralski process, and of inhibiting formation of dislocations within a single crystal grown by the process. The crucible includes a body of vitreous silica having a bottom wall and a sidewall formation extending up from the ...