Mutante menschlichen Wachstumhormone und deren Verwendung

Hormones de croissance humaines mutantes et leur utilisation

Mutant human growth hormones and their uses

Abstract

In accordance with the present invention, there are provided mutant human growth hormone proteins which exhibit enhanced affinity for growth hormone but lowered hormone activity, base sequences encoding the same and their production processes as well as uses of said proteins. The proteins according to the present invention, with their enhanced affinities for the growth hormone receptor, can inhibit the binding of growth hormone to its receptor, while they retain lowered growth hormone activities, thus finding application as a medicament for the treatment of acromegaly and gigantism.

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Patent Citations (2)

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NO-Patent Citations (1)

    Title
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 172, no. 1, 15 October 1990, ORLANDO, FL US, pages 357-363, XP002032925 E UCHIDA ET AL.: "An active site of growth hormone for eliciting the differentiation of preadipose 3T3-F442A cells to adipose cells"

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