ile (Total 101 Patents Found)

Ile (101 Patents Found)
本发明属于多肽合成领域,具体涉及Suc‑Ile‑Glu(γ‑Pip)‑Gly‑Arg‑pNA·HCl的制备方法。该方法采用双烯丙氧羰基(bis‑Alloc)对精氨酸的胍基进行保护,从而使其不受酸碱的影响;先将对苯二胺连接在氨基酸上,然后再以过氧化氢和三氟乙酸酐对...
La présente invention concerne l'utilisation du composé peptidique Arg-Asn-I Ie-AIa-Glu-lle-lle-Lys-Asp-lle-OH en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégénérative...
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3- oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in parti...
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in partic...
La présente invention concerne l'utilisation du composé peptidique His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégén...
A floating island with a water-purifying effect of the present invention has a floating body (11) and an agent container (12). The floating body (11) includes a planter (3) made of a foamed resin, soil contained in the planter (3) and plants (6) planted in the soil. A plurality of openings (32) are provided in the bott...
The present invention is directed to the use of the peptide compound His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, h...
本发明公开了一种基于LAMP技术快速鉴定含有Ile-1781-Leu突变的抗精恶唑禾草灵的菵草基因型的分子检测方法,可用于含有该种突变的菵草的早期预警和流行监测。该检测方法共分3个主要步骤,(1)分别提取待测样品的基因组DNA;(2)设计特异性引物...
The present invention is directed to the use of the peptide compound Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung ...
La présente invention concerne un procédé de marquage isotopique spécifique des acides aminés Valine, Leucine et Isoleucine. Le procédé selon l'invention emploie un acide 2-alkyl-2-hydroxy-3-oxobutanoïque où le substituant alkyle en position 2 est un groupement éthyle ou méthyle. La présente invention p...
La présente invention concerne l'utilisation du composé peptidique Pro-Gly-Thr-Cys-Glu-lle-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodé...
本发明以Tyr-Ile-Gly-Ser-Arg为先导结构,通过变换其C端氨基酸得到17种具有抗血栓活性的多肽。本发明公开了这些多肽及其合成方法。本发明的多肽的分子式为Tyr-Ile-Gly-Ser-AA,其中,AA选自缬氨酸、谷氨酰胺、赖氨酸、丙氨酸、色氨酸、丝氨酸、...
La présente invention concerne l'utilisation du composé peptidique Pro-Gly-Thr-Cys-Glu-lle-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodé...
本发明公开了氨基转移酶和异构酶在催化形成L-allo-Ile中的应用。所述的氨基转移酶为氨基转移酶DsaD或氨基转移酶MfnO,所述的异构酶为异构酶DsaE或异构酶MfnH,所述的氨基转移酶DsaD的氨基酸序列如SEQ?ID?NO.7所示,所述的异构酶DsaE的氨基酸序...
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in partic...
ABSTRACT An artificial island located on the high seas is formed by a support structure and a platform mounted on the upper end of the support structure. During erection, the support structure, not completed to its full height, is moved into position and founded on the ocean floor. The platform is the...
A floating island comprising one or more layers of nonwoven mesh material and optional buoyant nodules. The mesh material is optionally coated with a spray-on elastomer or inoculated with nutrients or microorganisms. The island can include buoyant growth medium, floats, buoyant blocks, a prefabricated seed blanket, a d...
A new heptapeptide having specific inhibitory properties for the release of aldosterone from the adrenal cortex has been found. The new compound resembles angiotensin II except for the two terminal amino acids. The N-terminal amino acid (aspartic acid) is absent, while the C-terminus is occupied by L-isoleucine....
La présente invention concerne un procédé de marquage isotopique spécifique des acides aminés Valine, Leucine et Isoleucine. Le procédé selon l'invention emploie un acide 2-alkyl-2-hydroxy-3-oxobutanoïque où le substituant alkyle en position 2 est un groupement éthyle ou méthyle. La présente invention p...
A process for the specific isotopic labeling of an amino acid selected from Valine (Val), Leucine (Leu), and Isoleucine (Ile), in proteins and biomolecular assemblies by introducing, in a medium containing bacteria overexpressing a protein, an acetolactate derivative of Formula I of the application....
<P>L'INVENTION CONCERNE UN DISPOSITIF POUR ABSORBER LES CHARGES D'IMPACTS DIRIGEES HORIZONTALEMENT SUR LES JAMBES DE SUPPORT D'UNE ILE ARTIFICIELLE COMPRENANT UN PONTON ET DES JAMBES MOBILES EN DIRECTION VERTICALE ET POUVANT ETRE BLOQUEES QUAND ELLES SONT ABAISSEES OU REMONTEES. LE DISPOSITIF EST CONS...
Procédé et dispositif de fabrication d'une structure (1) artificielle, notamment en forme de colonne, sur le fond d'un plan d'eau consistant à fabriquer, premièrement, une partie de la structure à une distance donnée de sa destination, sur une série de pontons (16) lesquels sont plaçés sur une surf...
The present invention is directed to the use of the peptide compound Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung ...
A new octapeptide having profound angiotensin antagonist properties has been found. The new compound resembles angiotensin II except for the two terminal amino acids, carrying an unnatural amino acid at the N-terminus....
PURPOSE: To prohibit the angiotensinogen cleavage action of proteolytic enzyme useful for the treatment of a renin-associated hypertension, hyperaldosteronism, and congestive heart failure. CONSTITUTION: The compd. of formula I [A is H, an aryl, etc.; B, D are formulas II, III (R 13 is H, a 1 to 5C alkyl, etc.;...
The invention provides application of cyclodipeptide cyclo-(L-Ile-L-Pro). Particularly, cyclodipeptide cyclo-(L-Ile-L-Pro) is applied to preparation of nematode insecticide, by measuring the fatality rate of meloidogyn incognita and the fatality rate of caenorhabditis elegans, it is found that cyclodipeptide cyclo-(L-I...
La présente invention concerne l'utilisation du composé peptidique His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégén...
The invention relates to cyclic peptide which is provided with a residue fragment of -Ile-Sta-Sta-Tyr- and is used as immunosuppressive agents, and the synthesis process of the cyclic peptide (Ile-Ile-Sta-Sta-Tyr-Val-Pro-Leu) is 1) removing amino-protecting groups, 2) transpeptidase reaction, 3) the cutting of peptide ...
La présente invention concerne l'utilisation du composé peptidique His-Pro-Gly-Ser-Arg-lle-Val-Leu-Ser-Leu-Asp-Val-Pro-lle-Gly-Leu-Leu-Gln-lle-Leu-Leu-Glu-Gln-Ala-Arg-Ala-Arg-Ala-Ala-Arg-Glu-Gln-Ala-Thr-Thr-Asn-Ala-Arg-lle-Lu-Ala-Arg-Val-NH2 en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au ...