leu (Total 172 Patents Found)

Leu (172 Patents Found)
A pharmaceutical formulation comprising a growth hormone and Leu-His-Leu as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissol...
The invention relates to a cyclic peptide which is provided with a residue fragment of -Val-Sta-Leu- and is used as immunosuppressive agents, and the synthesis process of the cyclic peptide (Ile-Ile-Pro-Pro-Tyr-Val-Sta-Leu) consists of 1) removing amino-protecting groups, 2) transpeptidase reaction, 3) the cutting of a...
Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said polynucleotides or any substantially homologous polynucleotides, the host cell modified with said polynucleotides or said re...
一种用于检测线粒体tRNALeu(UUR)3253T>C突变的试剂盒及其检测方法。所述方法包括DNA的提取、特异性引物设计、特异性条带PCR扩增、<u>专一</u>性限制性内切酶BstEII酶切、琼脂糖凝胶电泳鉴定等。本发明实现了几小时内出结果,且一种酶...
The present invention relates to a efficient expression of a protein, particularly, hirudin; a protein precursor comprising a signal sequence and the sequence of aa X -hirudin, wherein aa X is a selected amino acid, and aa X is preferably leucine; to its preparation and use; and to processes for finding signal sequen...
The present invention provides an antimicrobial composition containing cis -cyclo(L-Leu-L-Pro) as an active ingredient and having specific antimicrobial activity against the genus Streptococcus or bacteria of the genus Shigella , a pesticide composition, and a method for producing an antimicrobial agent. The presen...
La présente invention concerne l’utilisation d’un nanoconjugué polycéfine-LLL pour administrer des médicaments par voie cytoplasmique. Selon l’un des modes de réalisation, la présente invention utilise une molécule d’administration de médicament comprenant un échafaudage moléculaire d’acide carboxyl...
The present invention is directed to the use of the peptide compound His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, h...
This is an immunochemical assay that uses enzyme-linked immunosorbence to detect the presence of antibodies against environmental protein sequences that mimic the human opioid peptide dynorphin in samples of human body fluid. The assay makes it possible to correlate and diagnose psychobiological or medical disorders re...
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3- oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in parti...
La présente invention concerne l'utilisation du composé peptidique His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégén...
La présente invention concerne l'utilisation du composé peptidique Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neur...
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the pr...
The present invention is directed to the use of the peptide compound His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, h...
There is disclosed a pharmaceutical composition of stabilized [Leu¹³]-motilin-Hse. The composition comprises at least one of organic acids and salts thereof, as a first stabilizer, and pH thereof is adjusted in a range of 5.5 - 8.0. The composition may contain at least one of substances selected from saccharides, ami...
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in partic...
La présente invention concerne l'utilisation du composé peptidique His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégén...
La présente invention concerne un coussin corporel polyvalent conçu de façon économique. Le coussin procure un support pour la tête et la nuque, mais aussi pour l'ensemble du dos. Le coussin présente une forme rectangulaire pourvue d'une ouverture rectangulaire formée à travers celle-ci. De manière ava...
The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Poly...
The present invention is directed to the use of the peptide compound His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, h...
本发明公开了一种基于LAMP技术快速鉴定含有Ile-1781-Leu突变的抗精恶唑禾草灵的菵草基因型的分子检测方法,可用于含有该种突变的菵草的早期预警和流行监测。该检测方法共分3个主要步骤,(1)分别提取待测样品的基因组DNA;(2)设计特异性引物...
The invention discloses Arg-Leu-Val-Cys-Val and discloses a preparation method, analgesic activity, antitumor activity, antithrombotic activity and thrombolytic activity thereof. Therefore, the invention discloses application of the Arg-Leu-Val-Cys-Val in the preparation of analgesic drugs, antitumor drugs, antithrombo...
La présente invention concerne un procédé de marquage isotopique spécifique des acides aminés Valine, Leucine et Isoleucine. Le procédé selon l'invention emploie un acide 2-alkyl-2-hydroxy-3-oxobutanoïque où le substituant alkyle en position 2 est un groupement éthyle ou méthyle. La présente invention p...
The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Poly...
The present invention is directed to the use of the peptide compound Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH or its combination with the peptide Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, in...
本发明涉及一种辐照低浓铀箔靶件铀箔溶解装置,包括溶解器(1),所述溶解器(1)的底部设有加热器(3),溶解器(1)内穿设有进液管线(43)、气体吸收管线(44)以及出液管线(45);所述气体吸收管线(44)上依次设有限压单向阀(8)、气体吸收单元和气体储...
The present invention is directed to the use of the peptide compound Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH or its combination with the peptide Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, in...
本发明公开了氨基酸-(3,4-二羟基-Phe)-Ser-Leu伪肽及其合成方法和应用。其合成方法包括:(1)合成保护的(3,4-二羟基-Phe)-Ser-Leu;(2)将甘氨酸,丙氨酸,缬氨酸,亮氨酸,异亮氨酸,苯丙氨酸,酪氨酸,色氨酸,丝氨酸,苏氨酸,脯氨酸,谷氨酰...
La présente invention concerne des polynucléotides isolés, naturels ou synthétiques et les polypeptides codés par lesdits polynucléotides, lesquels sont impliqués dans la synthèse de cyclodipeptides, les vecteurs de recombinaison comprenant lesdits polynucléotides ou tous les polynucléotides sensiblement homo...
A method of producing a nuclear fuel product is provided. The method includes the steps of providing a core comprising aluminium and low-enriched uranium; and sealing said core in a cladding. The core has a low-enriched uranium loading strictly higher than 3.0 gU/cm 3 and includes less than 10 wt % of aluminium phase ...
The promoter of the gene encoding the enzyme 3-isopropylmalate dehydrogenase (IPMDH) has been cloned from the plant pathogenic fungus, Stagonospora nodorum. This promoter can be used to screen for inhibitors of expression of IPMDH. Inhibitors of the expression of IPMDH are useful as fungicides....
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in partic...
The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Poly...