thr (Total 137 Patents Found)

Thr (137 Patents Found)
The object of the invention is based on inhibiting specific phosphorylation on Thr248 and/or Thr250 residues of human transcription factor E2F4 to inhibit somatic endoreduplication processes in postmitotic cells which may be associated with various pathological conditions. The invention covers all currently known metho...
Disclosed are nucleic acid molecules encoding a protein interacting with the Ser/Thr kinase Akt as well as the encoded protein. Furthermore, the invention describes expression vectors, host cells, antibodies, pharmaceutical compositions and methods for treating disorders associated with impaired endosomal transport....
To provide a pyrazole derivative having a superior fluorinated substituent, which is useful for pharmaceutical products or agricultural chemicals having pharmacological activities, and a method for its production. A compound represented by the hollowing formula (A), wherein R f is a C 2-19 perfluoroalkyl group having...
Disclosed are nucleic acid molecules encoding a protein interacting with the Ser/Thr kinase Akt as well as the encoded protein. Furthermore, the invention describes expression vectors, host cells, antibodies, pharmaceutical compositions and methods for treating disorders associated with impaired endosomal transport....
The present invention relates to a new low-molecular spiro, ketone and carboxylic acid compounds and their derivatives having an affinity for (PO3H2)Ser/(PO3H2) Thr-Pro-specific peptidyl-prolyl-cis/trans-isomerases of the parvuline family and which inhibit their enzymatic peptidyl-prolyl-cis/trans-isomerase activity, a...
A new heptapeptide having specific inhibitory properties for the release of aldosterone from the adrenal cortex has been found. The new compound resembles angiotensin II except for the two terminal amino acids. The N-terminal amino acid (asparatic acid) is absent, while the C-terminus is occupied by L-threonine....
La présente invention concerne l'utilisation du composé peptidique Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neur...
La présente invention concerne l'utilisation du composé peptidique His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe en tant qu'agent thérapeutique destiné à la prophylaxie et/ou au traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodégén...
The invention relates to a liquid-phase synthetic method of a tetrapiptide and particularly relates to the liquid-phase synthetic method of tetrapiptide Thr-Pro-Pro-Thr, wherein a carboxyl in a C-terminal threonine of the tetrapiptide has an amide structure and an N-terminal of the tetrapiptide is a free amino group....
本发明属于生物技术领域,具体涉及一种聚酯连接的三价铁次血红素六肽及其制备方法。其首先在无水无氧条件下制备聚酯-NHS酯,然后与次血红素混合以DMSO为溶剂反应;反应结束后在水中将聚合物沉出,离心,收集沉出物,纯化干燥后,即得...
The present invention is directed to the use of the peptide compound Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular...
A field emitter device formed by a veil process wherein a protective layer comprising a release layer is deposited on the gate electrode layer for the device, with the protective layer overlying the circumscribing peripheral edge of the opening of the gate electrode layer, to protect the edge of the gate electrode laye...
The present invention is directed to the use of the peptide compound His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, h...
A continuously generated alkyleneamines producers composition comprising based on 100% of the moles of the compostion and exclusive of any MEA and water present, a) about 15 to about 35 mole % DETA, b) about 15 to about 55 mole % EDA (net generated), c) about 10 to about 35 mole % AEEA, d) about...
The invention provides new spiro and carboxylic acid derivatives, pharmaceutically compositions comprising them and their use for the preparation of pharmaceutical compositions....
本发明公开了一种新的多肽——人蛋白丝氨酸-苏氨酸磷酸酶14.30,编码此多肽的多核苷酸和经DNA重组技术产生这种多肽的方法。本发明还公开了此多肽用于治疗多种疾病的方法,如先天性心脑血管病、肿瘤、血小板功能障碍、糖尿病、感染、心...
The present invention is directed to the use of the peptide compound Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung ...
La présente invention concerne l'utilisation du composé peptidique Pro-Gly-Thr-Cys-Glu-lle-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodé...
The present invention is directed to the use of the peptide compound Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH or its combination with the peptide Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, in...
The present invention is directed to the use of the peptide compound Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH or its combination with the peptide Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, in...
The invention discloses novel TFA-Glu(OtBu)-Pro-Gly-Pro-Thr-Ala-OH synthesis technology. The synthesis technology is used to produce Boc-GLy-Pro-Thr-Ala-OH TFA under the action of TFA.GLy-Pro-Thr-Ala-OH and BOC-Glu(otBu)-Pro-Osu() in certain conditions and then to synthesize a more stable TFA-Glu(OtBu)-Pro-Gly-Pro-Thr-...
The fabric, drawn from its roll, comprises a number of adjacent woven lace strips linked to each other by bonding threads. The material is drawn off its roller and supported in a number of hanging loops, for the bonding threads to be located and passed to a rotating shaft, for them to be drawn off. The purpose is to pr...
La présente invention concerne la séquence d'un récepteur matriciel de cellule, spécifique de la région Cys-Ser-Val-Thr-Cys-Gly (SEQ ID NO:1) de la thrombospondine. L'invention concerne également la purification, le clonage et des procédés d'expression. La protéine réceptrice est utilisée dans de...
La présente invention concerne la séquence d'un récepteur matriciel de cellule, spécifique de la région Cys-Ser-Val-Thr-Cys-Gly (SEQ ID NO:1) de la thrombospondine. L'invention concerne également la purification, le clonage et des procédés d'expression. La protéine réceptrice est utilisée dans de...
本发明公开了一种新的四肽(TFA-GLy-Pro-Thr-Ala-OH)合成工艺。本发明的合成工艺是将Boc-GLy-Pro-Osu和TFA-Thr-Ala-OH在一定条件的作用下,生产Boc-GLy-Pro-Thr-Ala-OH TFA。再合成更稳定和可安全贮存的GLy-Pro-Thr-Ala-OH,质量符合标准要求。通过本工艺合成的TFA-GLy...
La présente invention concerne l'utilisation du composé peptidique Pro-Gly-Thr-Cys-Glu-lle-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH en tant qu'agent thérapeutique pour la prophylaxie et/ou le traitement du cancer, de maladies auto-immunes, de maladies fibreuses, de maladies inflammatoires, de maladies neurodé...
The present invention provides the sequence of a cell matrix receptor specific for the Cys-Ser-Val-Thr-Cys-Gly (SEQ ID NO:1) region of thrombospondin. Also provided are purification, cloning and expression methods. The receptor protein is useful in numerous diagnostic, prophylactic and therapeutic areas....
Methods of diagnosing cancer and screening for an anti-cancer drug using Ras are provided. Ras has a very significant role as a prevalent proto-oncogene which has abnormalities in most forms of cancer, and thus the methods of diagnosing cancer and screening for an anti-cancer drug using Ras may be applied to various fo...
La présente invention propose des compositions et procédés utiles pour préparer et utiliser des analogues, des dérivés et des modifications de kaempférols ayant une activité anti-néoplasique. Plus spécifiquement, les composés sont des analogues, des dérivés et des modifications de SLO1O1. L'invention p...
Cette invention concerne de nouveaux dérivés de spirocétone et d'acide carboxylique, des compositions pharmaceutiques contenant ces dérivés, et leur utilisation pour la préparation de compositions pharmaceutiques....
본 발명은 드럼 세탁기의 제작시 드럼 커버에 볼을 투입한 후 용접 위치로 취출시키는 작업을 자동으로 수행할수 있도록 한 드럼 세탁기용 드럼 커버의 제조 장치 및 방법에 관한 것으로, 본 발명은 드럼 커버의 프론트 드럼 커버에 볼을 투입...
本发明建立了一种线粒体tRNAThr?15909A>G突变检测方法及其试剂盒。所述方法包括DNA的提取、特异性引物设计、特异性条带PCR扩增、专一性限制性内切酶HpyCH4V酶切、琼脂糖凝胶电泳鉴定等。位于线粒体tRNAThr?15909A>G突变的DNA样本经特...
The present invention is directed to the use of the peptide compound Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung ...
무선랜에서의 통신 방법 및 이를 위한 무선 장치가 개시된다. 일 실시예에 따른 무선랜에서의 통신 방법은 스테이션(STA)은 하나 이상의 액세스 포인트들(APs)로부터 상위 계층 서비스 발견 프로토콜(upper layer service discovery protocol) 정보가 포함...
The invention relates to the preparation of a Ser/Thr-kinase as a target for fungicides involved in autophagocytosis, to a method for identifying fungicides which inhibit a polypeptide due to the activity of a Ser/Thr kinase involved in autophagocytosis, and to the use of said compounds identified by the above mentione...
PURPOSE: A method of making a formulation of lactic acid bacteria powder such as sugar beads by spraying polysaccharide aqueous solutions to refined sugar to make central seeds, spraying the polysaccharide aqueous solutions to the central seeds and drying is provided. It maximizes efficacy of lactic acid bacteria in th...